Sulfaprim suspension
Group affiliation: Antimicrobial combined agent
Composition: Each 5 ml suspension contains active substances: 40 mg trimethoprim, 200 mg sulfamethoxazole
Pharmachologic effect: Sulfaprim® refers to antibacterial drugs. It is used in the treatment of infections caused by antibiotic-sensitive microorganisms. Sulfamethoxazole competitively inhibits the utilization of para-aminobenzoic acid by microbial cells during the synthesis of dihydrofolic acid, thereby stopping the growth of microbial cells. Trimethoprim reversibly inhibits the reductase that converts folic acid to dihydrofolic acid, thereby disrupting its conversion into the active form (tetrahydrofolic acid). This manifests its bactericidal effect Thus, trimethoprim and sulfamethoxazole inhibit two successive stages of purine synthesis, as a result of which nucleic acids become indispensable for many microorganisms. Under in vitro conditions, this leads to the potency of the activity of two factors.
